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The real question: Will either medication achieve the sustained, widespread use needed to address the global obesity epidemic

Unlike GnRH agonists that create an artificial menopause to suppress estrogen, the weight-mediated estrogen reduction through GLP-1 agonists is more physiological

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partly for this reason, some promising treatments are never approved, and many arrive too late for people who urgently need them

Experimental data indicate that increased PER1 expression may enhance the susceptibility of tumor cells to ionizing radiation, potentially affecting thresholds for radiation-induced cell death in in vitro and in vivo systems